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Salmon DNA for Acne Treatment — also known as PN/PDRN therapy (polydeoxyribonucleotide or polynucleotide therapy) — is a rising trend in regenerative aesthetics and dermatology. While traditionally used for anti-aging and skin revitalization, it's now being explored for acne-prone and inflamed skin due to its healing, anti-inflammatory, and skin barrier-restoring properties.

🔹 What is Salmon DNA (PN / PDRN) Therapy?

• Derived from salmon sperm DNA, PN (Polynucleotides) and PDRN (Polydeoxyribonucleotides) are bioactive DNA fragments.
• When injected into the skin (or applied via microneedling), they act as bioregulators, stimulating:
  Tissue repair
  Collagen synthesis
  Anti-inflammatory cytokines
  Fibroblast activation
• It’s non-immunogenic (very low allergy risk), making it safe for sensitive and acne-prone skin.
• 🔬 How It Helps Acne

Anti-inflammatory action.Reduces active breakouts, redness, and swelling

Improves skin barrier.Strengthens skin’s defenses, reduces transepidermal water loss (TEWL)

Stimulates healing.Helps fade post-acne marks, boosts tissue regeneration

Reduces sebum and bacterial proliferation.Indirectly minimizes acne triggers

Pairs well with other treatments. Can be safely combined with LED light therapy, and mild peels

🔹 Best Use Cases in Acne Treatment

• Inflamed acne with compromised barrier
• Post-acne red or pigmented marks (PIE/PIH)
• Sensitive or reactive skin with acne history
• Patients intolerant to retinoids or antibiotics
• Supporting tissue healing after acne procedures (e.g. extractions, peels, laser)

🔄 Recommended Pairings

PN injection + Red LED light: Reduces inflammation and boosts healing

PN + Microneedling: Enhances penetration and collagen remodeling

PN + BHA peel (mild): Controls oil, reduces congestion while healing skin

PN + BPC-157 (peptide):Synergistic for repair and scar prevention

PN + IV Glutathione or Vit C: Brightens skin, supports detox, reduces pigmentation

🕒 Treatment Protocol (Example)

• Initial Phase: 3 sessions every 2–3 weeks
• Maintenance: 1 session every 4–6 weeks
• Method: Microinjection (mesotherapy)
• Add-ons: Red/NIR light therapy immediately after for inflammation control

⚠️ Safety & Side Effects

• Extremely well-tolerated
• Minor pinpoint bruising or swelling at injection sites
• Not suitable for patients with fish allergies (rare)